AP source: Obama poised to pick Perez for Labor

FILE - In this Thursday, May 10, 2012 file photo, United States Assistant Attorney General Thomas Perez, left, who heads up the civil rights division at the Department of Justice, is joined by Deputy Assistant Attorney General for Civil Rights, Roy Austin, as Perez announces a federal civil lawsuit against Maricopa County Sheriff Joe Arpaio during a news conference in Phoenix, after months of negotiations failed to yield an agreement to settle allegations that Arpaio's department racially profiled Latinos in his trademark immigration patrols. Two people familiar with the process say President Barack Obama is close to naming Perez as his choice to head the Department of Labor. (AP Photo/Ross D. Franklin, File)

FILE - In this Thursday, May 10, 2012 file photo, United States Assistant Attorney General Thomas Perez, left, who heads up the civil rights division at the Department of Justice, is joined by Deputy Assistant Attorney General for Civil Rights, Roy Austin, as Perez announces a federal civil lawsuit against Maricopa County Sheriff Joe Arpaio during a news conference in Phoenix, after months of negotiations failed to yield an agreement to settle allegations that Arpaio's department racially profiled Latinos in his trademark immigration patrols. Two people familiar with the process say President Barack Obama is close to naming Perez as his choice to head the Department of Labor. (AP Photo/Ross D. Franklin, File)

WASHINGTON (AP) ? President Barack Obama is close to naming Thomas Perez, a civil rights official in the Justice Department, as his choice to head the Department of Labor, two people familiar with the process say.

His nomination could come as early as Monday, the people familiar with the process said Saturday. They spoke on condition of anonymity because they were not authorized to speak prior to the official announcement.

If confirmed, Perez would replace Hilda Solis, who resigned in January.

White House spokesman Matt Lehrich declined to comment.

Perez, 51, has led the Justice Department's Civil Rights Division since 2009 and previously served as Maryland's labor secretary. He is expected to have solid support from organized labor as well as the Hispanic community, which is eager to have representation in Obama's second-term Cabinet.

Solis was the first Hispanic woman to head an agency at the Cabinet level. Perez was the first Latino elected to the Montgomery County Council in Maryland, where he served from 2002 to 2006.

Perez would come to the Labor Department as Obama pushes a major immigration overhaul, which could include changes in how employers hire guest workers. Labor Department officials have also taken a prominent role in supporting Obama's effort to raise the federal minimum wage from $7.25 to $9 an hour.

At the Justice Department, Perez played a leading role in the decision to challenge voter ID laws in Texas and South Carolina that could restrict minority voting rights. A federal court later struck down the Texas law and delayed implementation of the law in South Carolina until after the 2012 election.

Perez was easily confirmed by the Senate for his Justice Department post, but since then, some GOP lawmakers have criticized his role in persuading the city of St. Paul, Minn., to withdraw a lending discrimination lawsuit from the Supreme Court. In exchange, the Justice Department declined to join two whistle-blower lawsuits against St. Paul that could have returned millions of dollars in damages to the federal government.

The St. Paul case had challenged the use of statistics to prove race discrimination under the 1968 Fair Housing Act, and Justice Department officials were concerned the court could strike down the practice.

A letter last year from four Republican lawmakers, including Sen. Chuck Grassley of Iowa and Rep. Darrell Issa of California, criticized Perez for a "quid pro quo arrangement" that potentially cost taxpayers more than $180 million.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-03-10-Labor%20Secretary/id-25d9401bd2a94bf2a9e6396e4a267fd2

don draper gallagher madmen james cameron liam hemsworth miss canada justin bieber boyfriend

Fidel Castro laments loss of 'best friend' Chavez

HAVANA (AP) ? Retired leader Fidel Castro broke nearly a week of silence since the death of friend and ally Hugo Chavez, saying Monday that Cuba has lost its "best friend" with the late Venezuelan president's passing.

In an article published on the front page of Communist Party newspaper Granma, Castro said that while it had been clear that Chavez's life was threatened by a recurring cancer affliction that prompted four surgeries, word of his death on March 5 nonetheless came as a bitter shock.

"The best friend the Cuban people have had in the course of their history passed away. ... Although we knew of his critical state of health, the news was a strong blow," Castro wrote.

The 86-year-old Castro, who has been out of power since a near-fatal intestinal ailment forced him from office in 2006, has ceased penning his once-regular opinion pieces, known as "Reflections."

Last October, amid the latest round of rumors about his own health, Castro explained that he decided to do so not because he was ill but because they were taking up valuable space in state media that was needed for other purposes.

In life, Chavez often referred to Castro as a father figure, mentor and close friend, and after he first won election in 1998, Havana and Caracas grew increasingly close.

Chavez supplied Cuba with billions of dollars in subsidized oil to help prop up the island's listing economy, while Havana sent tens of thousands of doctors, teachers, sports trainers and political advisers to work in Venezuela.

Venezuela has become Cuba's No. 1 trading partner.

Following Chavez's latest surgery in Havana in December, Castro said he checked in on the Venezuelan president's health daily.

On Monday, he recalled that Chavez once invited him to go on a riverboat excursion in Venezuela once the two leaders' "revolutionary task" was finished.

Invoking Cuban independence hero Jose Marti and 19th century Venezuelan liberator Simon Bolivar, Castro said it had been an honor to have been Chavez's ally.

"Not even he suspected how great he was," Castro wrote. "Onward to victory always, unforgettable friend!"

Spain's Prince Felipe arrives with other heads-of-state for the funeral of late Venezuelan President Hugo Chavez at the Military Academy in Caracas March 8, 2013, in this picture provided by the ... more? Spain's Prince Felipe arrives with other heads-of-state for the funeral of late Venezuelan President Hugo Chavez at the Military Academy in Caracas March 8, 2013, in this picture provided by the Miraflores Palace. Chavez will be embalmed and put on display "for eternity" at a military museum after a state funeral and an extended period of lying in state, acting President Nicolas Maduro said on Thursday. REUTERS/Miraflores Palace/Handout (VENEZUELA - Tags: POLITICS OBITUARY ROYALS ENTERTAINMENT) ATTENTION EDITORS - THIS IMAGE WAS PROVIDED BY A THIRD PARTY. FOR EDITORIAL USE ONLY. NOT FOR SALE FOR MARKETING OR ADVERTISING CAMPAIGNS. THIS PICTURE WAS PROCESSED BY REUTERS TO ENHANCE QUALITY. AN UNPROCESSED VERSION WILL BE PROVIDED SEPARATELY less?

___

Follow Peter Orsi on Twitter: www.twitter.com/Peter_Orsi

Source: http://news.yahoo.com/fidel-castro-laments-loss-best-friend-chavez-170139302.html

d t p zynga Tropical Storm Sandy W S

Mutated gene causes nerve cell death

Mar. 10, 2013 ? The British astrophysicist Stephen Hawking is likely to be the world's most famous person living with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. ALS is a progressive disease affecting motor neurons, nerve cells that control muscle function, and nearly always leads to death. Researchers at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) in Vienna have now identified a completely new mechanism in the onset of motor neuron diseases. Their findings could be the basis for future treatments for these presently incurable diseases.

A new principle on motor neuron death

The IMBA scientists, working with an international team of researchers under the leadership of Josef Penninger and Javier Martinez, discovered a completely new fundamental mechanism that triggers the death of motor neurons. Motor neurons are nerve cells responsible for stimulating muscles. The loss of these motor neurons in mice with a genetic mutation in a gene named CLP1¹ leads to severe and progressive muscular paralysis and, in some cases, to death.

"We've been working on resolving the function of the CLP1 gene in a living organism for a long time. To do that, we developed model mice in which the function of CLP1 was genetically inactivated. To our utter surprise we discovered that deactivating CLP1 increases the sensitivity of cell die when exposed to oxidative stress². That leads to enhanced activity of the p53 protein³ and then to the permanent destruction of motor neurons," says Toshikatsu Hanada, a postdoctoral researcher working in the lab of Josef Penninger and first author of the study along with Stefan Weitzer.

Stephen Hawking -- a most renowned patient

Motor neuron diseases (MNDs), such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), are chronic disorders of the neuromuscular system. These diseases are caused by damage in the motor nerve cells in the brain and spinal cord, and the nerves can no longer stimulate motion in the muscles. The primary symptoms are muscular weakness, muscular dystrophy, and problems swallowing or speaking. Stephen Hawking was diagnosed with ALS 50 years ago. But not all ALS patients live so long with the disease: so far there are no treatments for ALS. Nearly all ALS patients die of paralysis of respiratory muscles within a few years.

Completely new disease mechanism

Javier Martinez, an IMBA team leader and co-author of the study, is a specialist in the field of ribonucleic acid (RNA) research. His research group had discovered the CLP1 gene in an earlier study, published in Nature in 2007. Until now, the exact essential function of CLP1 in RNA biology was unclear. "By deactivating CLP1, we have discovered a previously unknown new species of RNA," says Javier Martinez about the scientific relevance of the work. "The accumulation of this RNA is a consequence of increased oxidative stress in the cell. We see this as one of the triggers for the loss of motor neurons that occurs in ALS and other neuromuscular diseases. Thus our findings describe a completely new mechanism of motor neuron diseases."

Seminal findings

Josef Penninger, scientific director at the IMBA and last-author of the study, is excited about the researchers' findings: "This surprising discovery of a role of CLP1 in the onset of motor neuron diseases is an entirely new principle in how RNA talks to oxidative stress. Nearly all genetic mutations found in ALS patients affect either RNA metabolism or oxidative stress, suggesting a possibly unifying principle for these diseases. Our work may have revealed the 'missing link' in how these two biological systems communicate and trigger incurable diseases like ALS."

Stefan Weitzer sees tremendous potential for these findings: "We've discovered a new mechanism that leads to the death of motor neurons. If this holds true for other neuronal disease, our results could be one day used to drive the development of treatments for previously incurable diseases. In our work we also describe how the p53 protein regulates the loss of motor neurons. Removing p53 saves mice with CLP1 mutations from certain death." If scientists are successful in applying these findings to people, the researchers may have discovered a treatment approach to cure ALS and similar diseases. The authors, however, caution that more studies will be needed to translate their findings to human medicine.

This study was performed in collaboration with research groups from the Medical Universities of Vienna and Innsbruck, the University Medical Center at Hamburg-Eppendorf in Germany, the Harvard Medical School, the Harvard Stem Cell Institute, the Boston Children's and Massachusetts General Hospitals, the Keio University School of Medicine in Tokyo, Oita University in Japan, and the Weizmann Institute of Science in Rehovot in Israel.

Notes:

¹⁾ CLP1: = Cleavage and Polyadenylation Factor 1: a kinase (enzyme responsible for transmitting signals in cells) responsible for attaching phosphate residue to RNA.

²⁾ Oxidative stress: causes damage to cells and the genome, and is involved in the ageing process. The normal repair and detoxification function of the cells is overburdened.

³⁾ p53: a protein that is mutated in many types of cancer cells. It plays a role in inhibiting the cell cycle and can trigger cell death.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by Institute of Molecular Biotechnology.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Toshikatsu Hanada, Stefan Weitzer, Barbara Mair, Christian Bernreuther, Brian J. Wainger, Justin Ichida, Reiko Hanada, Michael Orthofer, Shane J. Cronin, Vukoslav Komnenovic, Adi Minis, Fuminori Sato, Hiromitsu Mimata, Akihiko Yoshimura, Ido Tamir, Johannes Rainer, Reinhard Kofler, Avraham Yaron, Kevin C. Eggan, Clifford J. Woolf, Markus Glatzel, Ruth Herbst, Javier Martinez, Josef M. Penninger. CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature, 2013; DOI: 10.1038/nature11923

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/oPMO9DA-PFA/130310163827.htm

dallas clark litter marinol flight attendant pau gasol trade michael madsen spring forward

American Idol Top 10: Who Made It?

Source:

Sally Ride Ichiro minka kelly James Holmes court Rupert Sanders bachelorette penn state

Video: NFL Draft preview: Top five WRs

Sorry, Readability was unable to parse this page for content.

Source: http://nbcsports.msnbc.com/id/21134540/vp/51090966#51090966

Sandy Hook Elementary School Colors Cassadee Pope Victoria Soto nbc sports morgan freeman westboro baptist church Survivor Philippines

Those opposed to Redskins name take case to judges

WASHINGTON (AP) -- As someone who has spent nearly a third of her life fighting the Washington Redskins nickname, Suzan Shown Harjo had a good laugh when asked about the team's latest line of defense.

Redskins general manager Bruce Allen said last month that it is "ludicrous" to think that the team is "trying to upset anybody" with its nickname, which many Native Americans consider to be offensive.

That's beside the point, according to Harjo. She's never suggested that the Redskins deliberately set out to offend anyone. But that doesn't mean that people aren't offended.

"It's just like a drive-by shooting," Harjo said Wednesday. "They're trying to make money, and not caring who is injured in the process ? or if anyone is injured in the process. I don't think they wake up or go to sleep dreaming of ways to hurt Native people. I think they wake up and go to sleep thinking of ways to make money ? off hurting Native people."

The long-running battle over the name gets a restart Thursday, when a group of Native Americans goes before the Trademark Trial and Appeal Board to argue that the Redskins should lose their federal trademark protection, based on a law that prohibits registered names that disparaging, scandalous, contemptuous or disreputable.

Harjo has won this round before. She was one of the plaintiffs when the board stripped the Redskins of the trademark in 1999, but the ruling was overturned in 2003 in large part on a technicality. Essentially, the courts decided that the plaintiffs were too old, that they should have filed their complaint soon after the Redskins registered their nickname in 1967, or shortly they became adults and therefore old enough to file a case.

So this new case was begun in 2006 by a different group of Native Americans, with ages ranging from 18 to 24 at the time it was filed. For various reasons, it's taken seven years for it to get this far. It's now been 21 years since Harjo, now 67, filed the original case.

"It's not what I do every breathing hour, but it's been that long since I've become a thing rather than a person," said Harjo, who is president of the Washington-based Morning Star Institute, an advocacy group. "By that, I mean I'm the 'Harjo case.' And people talk to me sometimes, saying, 'Well, in Harjo, da-da da-da da-da.' It is a little startling."

The motive is to force Redskins owner Dan Snyder into a change by weakening him financially. Redskins lawyer Robert Raskopf said during the previous case that the team would suffer "every imaginable loss you can think of" if it no longer had the exclusive marketing rights to its name.

A Redskins spokesman said the team would have no comment Wednesday. Snyder has always vowed not to change the name, and the team has said that it is meant to honor Native Americans, not ridicule them. Allen said last month that a change isn't being considered.

"There's nothing that we feel is offensive," Allen said. "And we're proud of our history."

The name debate has generated off-and-on discussion in the nation's capital over the decades, but there's been a renewed momentum in recent weeks. The Redskins were denounced time and again at a daylong symposium at the Smithsonian last month, and politicians and local columnists have since either expressed reservations about the name or condemned it outright.

"You stack up more and more, greater support," Harjo said.

Previous predictions of an impending change, however, have not borne fruit. In 1998, while pursuing the first case, Harjo said: "I fully expect these names to be a thing of the past in 10 years. I think that will happen whether or not we win this suit."

___

Follow Joseph White on Twitter: http://twitter.com/JGWhiteAP

Source: http://news.yahoo.com/trademark-judges-hear-case-vs-002303023.html

nfl 2012 schedule gmail down tim lincecum ryan oneal file taxes online tupac shakur sledge hammer

We have 85 Scholarships on our Greatest College Football Players of All-Time ros...

Facebook logo

Email or Phone
Keep me logged in

Sign UpConnect and share with the people in your life.

The link you followed may be broken, or the page may have been removed.

Go back to the previous page ? Go to the Facebook homepage ? Visit the Help Center

Mobile	Find Friends	Badges	People	Pages	Places	Apps	Games	Music
About	Create an Ad	Create a Page	Developers	Careers	Privacy	Cookies	Terms	Help

Facebook ? 2013 ? English (US)

Source: http://www.facebook.com/permalink.php?story_fbid=10151257297392115&id=107496992114

jeb bush sherry arnold snooty fox el debarge portland weather clintonville battlestar galactica blood and chrome

literature review on the impact of using auto-responder for online ...

2.1???? INTERNET (ONLINE)

????????? An internet is a network of computers, which operates world wide using a set of protocols.

??????????? A website is to the internet as a market shade is to the market. (Recall that a market is where buying and selling can take place).

??????????? Burton and minus (1960) states that ?those wishing to sell market rent a shop or a market store or shade, where they display their goods. Those who want to buy from the market need not to acquire a shade?. The internet, which at the moment have over790 million users (growing at the rate of 100 thousand new users per day).

??????????? Similarly, Lucy (1997) states that ?The internet is a very big market, so if one wants to sell on the internet, the person must acquire a website where documentations can be exchanged. Online goods and services can stored much as a trader stores his goods in a market shade?.? Those not wishing to sell but might buy or obtain free information on the web need not to acquire a website.

2.2?????? ELECTRONIC COMMERCE

??????????? Electronic commerce or e-commerce is a term for any type of business, or commercial transaction that involves the transfer of information across the Internet. E-commerce allows consumers to electronically exchange goods and services with no barriers of time or distance ( Ugah and Ukpai, 2009) .To participate in electronic commerce, the following is important.

???????? Online business automation

???????? Website

2.2.1?? Auto responder

??????????? The use of auto responder for online supermarket maximizes profit for online businessmen due to the promptness of its response to queries or online forms submission.

??????????? There are several automations, which promote online business but among all, auto responder is of very much importance. As the internet user request for some information or service in your online business, an auto responder (if installed) sends an automatic reply to tell the visitor that he/she has been received and he/she is receiving urgent attention and he will be communicated in a due course. But because the visitor that makes the uniform resource locator request might not be aware that it was a computer programmed that is responding, he becomes impressed that he was able to retain a relevant instantaneous respond from your website.

2.2.1.1??????????? History of Auto-responder

An?auto-responder?is a?computer program?that automatically answers?e-mail?sent to it. They can be very simple or quite complex. The first auto-responders were created within?mail transfer agents (software that transfers electronic mail messages from one computer to another using client?server?application architecture)?that found they could not deliver an e-mail to a given address. They created?bounce messages?such as "your e-mail could not be delivered because..." type responses. Today's auto-responders need to be careful to not generate?e-mail backscatter, which can result in the auto-responses being considered?E-mail spam. Auto-responders are often used as e-mail marketing tools, to immediately provide information to their prospective customers and then follow-up with them at preset time intervals.

Such?follow-up auto-responders?can be divided into two categories:

• Outsourced ASP (Active server page) model ? these auto-responders operate on the provider's infrastructure and are usually configurable via a web-based control panel. The customer pays a monthly usage fee. This is easiest to implement for the end-user.

• Server-side ? enables users to install the autoresponder system on their own server. This requires technical skills.

Auto-responders are also incorporated into?electronic mailing list?software, to confirm subscriptions, unsubscriptions, posts, and other list activities.

2.2.3?? Website

??????????? The web and internet links provided in the website is often called the World Wide Web (www) which is actually a distributed multimedia hypertext system that is based on client/server architecture. An internet website name normally starts with http://www. where http stands for hypertext transfer protocols and www stands for World Wide Web. Http is set of rules for communication between www clients and server.

??????????? A website name (location), including its full part, is also known as uniform resource locator (URL). Therefore, URL can be regarded as the address of object in the World Wide Web. For example, the website of that organisation (online supermarket) will be on the internet so that the customers will browse the net and get the address of the organisation for purpose of buying and selling of goods online or advertisement of commodities.

2.3?????? Nature of Electronic Commerce

??????????? E-commerce comprises business transaction conducted using electronic communications processes and other facilities especially the internet. Within that broad definition, there are two categories of interest.

?? Trade in Physical Goods

This is a situation where goods are published on the internet and buyers from all over the world can login and purchase goods and pay over the internet and the goods will be delivered to them on a later time. A good example is amazon.com. In theory, consumers in African countries can now purchase goods from anywhere on the globe by placing orders and paying over the internet. Perhaps more importantly, African entrepreneurs have the world ass their oyster, being able to advertise their products, receive orders, ship, ship and receive payment electronically, ?leaving the playing field? and enjoying vastly larger markets for their goods (Ugah and Ukpai, 2009).

?? Trade In Offline Teleservices And Virtual Goods.

Many services such as capturing medical records, digitalizing architectural drawing, translating computer programs, etc. do not have to be done at a client?s physical premises, and there are also some so-called virtual goods like downloadable music files and digital images that can be created anywhere for electronic delivery to the client. All that is necessary for this type of trade is effective electronic communications.

Source: http://martinslibrary.blogspot.com/2013/03/literature-review-on-impact-of-using.html

kevin kolb sarah shahi rutgers dharun ravi george clooney arrested ravi leigh

I gotta be me (Unqualified Offerings)

Share With Friends: | | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/289321303?client_source=feed&format=rss

branson mo monkees songs rail gun harrisburg top chef texas great pacific garbage patch ben affleck and jennifer garner